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Thinking

One place for the writing, not a fragmented blog. The newsletter archive and long-form pieces on where CSV, CSA and AI in GxP are heading, plus the frameworks and the book. Read inside the quality and IT compliance functions of global pharma.

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The newsletter

Monthly insight on AI governance, digital quality, and the future of pharma compliance. Read by 9,000+ pharma professionals across LinkedIn and Substack. No filler.

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The archive

Essays and editions

Practice

Digital Transformation in Pharma, Part 2: From Strategy to Real Implementation

Most transformations fail because the governance is absent, not the technology. What real implementation looks like.

January 2026
Strategy

Why 70% of Pharma Transformations Fail (and how to be in the 30%), Part 1

Root-cause analysis of transformation failures and the governance structures that separate the programmes that work.

January 2026
Regulation

AI Will Not Remove Documentation in Validation. It Will Remove Uncertainty.

Where AI genuinely changes the validation equation, and where human judgment stays irreplaceable.

December 2025
Regulation

The Future of Pharma Compliance: How Draft Annex 11 Will Transform CSV

Draft Annex 11 signals a shift in how regulators think about computerized systems. What it means for your strategy.

July 2025
Practice

The Evolving Role of CSV Professionals

The CSV professional of 2020 and of 2026 are different roles. The skills that got you here won't get you there.

May 2025
Regulation

FDA's Refreshed Guidance on Electronic Systems in Clinical Trials

A CSV expert's reading of the updated guidance, with implications far beyond clinical.

April 2025
Regulation

The Need for Caution in Using AI for GxP Compliance

AI in GxP is not a silver bullet. Where caution is warranted and where enthusiasm is justified.

2025
Strategy

Transitioning from CSV to CSA: A Practical Guide

A step-by-step guide for organisations making the CSV to CSA transition under GAMP 5 Second Edition.

2024
Strategy

Revolutionise Your Validation Approach: CSV to CSA Masterclass

A strategic overview of risk-based thinking and modern validation approaches.

2024
Practice

Critical Thinking in Data and Audit Trail Reviews

Why critical thinking matters more than checklists in data integrity and audit trail assessments.

2024
Practice

Quality Management Systems 2.0, Part 2: Digitalization and Automation in Pharma 5.0

Implementation strategies for AI-assisted deviation management and CAPA automation.

2024
Practice

Quality Management Systems 2.0, Part 1: The Operating Model

Defines the QMS 2.0 operating model and its application to deviation and CAPA workflows.

2024
Practice

The Story of Misleading Job Descriptions

A candid look at how job descriptions in pharma IT quality often misrepresent the actual role.

2024
Strategy

Qualifying SaaS and IaaS: Creating Quality Agreements

Practical guidance on building quality agreements for cloud-hosted GxP systems.

2023
Strategy

Hyperautomation: How It Can Change CSV Forever

How RPA, AI and ML can reshape the validation lifecycle from end to end.

2023
Strategy

Automation vs Hyperautomation in CSV

Understanding the distinction between simple automation and hyperautomation in validation.

2023
The book

Validating AI in GxP: the practitioner's guide →

Pre-book now, get the launch discount.

Full editions live on the newsletter. Read the archive →